Science Signaling

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

MEG3-4 is a miRNA decoy that regulates IL-1 beta abundance to initiate and then limit inflammation to prevent sepsis during lung infection

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

Splenic leukocytes define the resolution of inflammation in heart failure

Thyroid hormone receptor and ERR. coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors

Host mitochondria influence gut microbiome diversity: A role for ROS