Signal Transduction And Targeted Therapy

Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer

Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9

MKP-1 reduces A beta generation and alleviates cognitive impairments in Alzheimer's disease models

The roles of prostaglandin F-2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes

Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models

Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis

The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma

Therapeutic effects of a novel BAFF blocker on arthritis

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer